INSTITUT D’ELEVAGE ET DE MEDECINE VETERINAIRE DES...
INSTITUT D’ELEVAGE ET DE MEDECINE
VETERINAIRE DES PAYS TROPICAUX
REVUE D’ÉLEVAGE
ET DE
MÉDECINE VÉTÉRINAIRE
*
DES PAYS TROPICAUX
a
The histological relationship hetween
« peste des petits ruminants »
and kata in West Africa
by A. C. ROWLAND and P. BOURDIN
1
Tome XXIII (nouvelle série)
No 3 - 1970
i
VIGOT FRERES, EDITEURS
23, rue de I’Ecole-de-Médecine, Paris-VI”
Rev. Elev. Méd. vét. Pays trop., 1970, 23 (3): 301-07
The histological relationship between
« peste des petits ruminants D and kata in West Africa
by A. C. ROWLAND and P. BOURDIN
S U M M A R Y
The histopathology of « Peste des Petits Ruminants (P.P.R.) » and Kata
was compared. The lesions demonstrated a close similarity, with necrosis
of alimentary tract epithelium, degeneration and proliferation in respi-
ratory epithelium and depression of lymphoid tissues. Intranuclear and
intracytoplasmic inclusion bodies occurred constantly in epithelial tissues.
RESUME
L’histopathologie comparée de la Peste des Petits Ruminants (P.P.R.)
et de la « Kata » montre que les lésions sont identiques avec en particulier
une nécrose de l’épithélium du tractus digestif, une dégénérescence et une
prolifération dans l’épithélium du tissu pulmonaire et un appauvrissement
du tissu lymphoïde.
La présence d’inclusions intranucléaires et intracytoplasmiques est
constante dans les tissus épithéliaux.
INTRODUCTION
of lesions over the lips, severe diarrhoea and
catarrhal inflammation of the respiratory tract.
For many years, a disease of the West Afri-
At post-mortem exam’ination, erosions may be
cari dwarf goat, « Peste des Petits Ruminants »
observed in the mouth, pharynx and oesopha-
(P.P.R.), has been known in West Africa
gus. In the intestine, congestion of the ileo-
(GARGADENNEC and LALANNE, 1942;
caecal valve and longitudinal folds of the large
\\
MORNET, ORUE, GILBERT, THIERY and
bowel is a common feature and in addition to
SOW MAMADOU, 1956).
respiratory tract inflammation, the lungs may
show consolidation of individual lobules.
The causal agent of P.P.R. is a paramyxo-
virus similar to, although larger than the para-
This paper compares the histopathological
;r
myxoviruses of measles, distemper and rinder-
changes observed in these two diseases. The
pest. (BOURDIN and LAURENT, 1967;
study was carried out at the Laboratoire Natio-
LAURENT, 1968).
nal de TElevage et de Recherches Vétérinaires
,
in Dakar-Hann, Dakar, Sénégal.
A transmissible disease of the West African
dwarf goat resembling rinderpest was first
described in Nigeria in 1965 (WHTTNEY,
MATERIAL AND METHODS
SCOTT and HILL, 1967; ROWLAND,
SCOTT and HILL, 1969) and provisionally
The P.P.R. sections were provided by cour-
named Kata.
tesy of the Director, M. ORUE. The Kata
The two diseases, P.P.R. and Kata, show
sections were prepared at the University of
clinically an erosive stomatitis with extension
Ibadan, Nigeria. Both the P.P.R. and the Kata
- 301 -
material had been obtained from acute experi-
gical change. Essentially, the most prominent
mental infections.
cellular changes were degenerative and necroti-
sing, sometimes overlaid by a marked prolifer-
The tissues examined were from the alimen-
ation from the surviving epithelial ce&.
tary and respiratory systems and from the
muco-cutaneous junctions. These had been
Alimentary tract
fixed in 10 per cent formol saline or Bouin’s
fluid, embedded in paraffin wax and stained
Lesions of the Upper alimentary tract devel-
by haematoxylin and eosin.
oped within the stratum spinosum and granu-
losum. Affected cells showed changes varying
from vacuolation to coagulation with nuclear
RESULTS
pyknosis and karyorrhexis. Syncytial aggre-
gations occurred from time to time (Fig. 1).
Histologically, the two diseases, P.P.R. and
Inclusion bodies were observed, both intra-
Kata, presented a similar pattern of patholo-
nuclear and intracytoplasmic in
situation
Fig. 1. - Mucosa tongue. Early lesions showing a
Fig. 1. - Muqueuse de la langue. Lésions précoces
syncytium (A), foci of necrosis (B) and vacuolation of
montrant un syncytium (A), des foyers de nécrose
the mucosal epithelium. Haematoxylin and Eosin.
(B) et une vacuolisation de la muqueuse épithéliale.
(X 200).
Hématoxyline-Eosine (X 200).
(Figs. 2 and 3). These were usually brightly
but haemorrhage was not observed. Intracyto-
eosinophilic or occasionally slightly ampho-
plasmic and intranuclear inclusion bodies,
philic, round or oval in the nucleus and often
similar in form to those in the oral cavity,
fragmented in the cytoplasm. The degenerate
were distributed throughout the mucosal epithe-
epithelium was rapidly eroded leaving only a lium (Figs. 4 and 5) in variable numbers.
scanty debris above the surviving stratum ger-
Occasionally, they were numerous.
minativum.
Respiratory system
The stomach and intestines showed necrosis
of the epithelium, both superficially and in
The respiratory tract showed mucosal necro-
the deep glands with loss of villi in the small
sis and hyperplasia. Again vacuolation and
intestine. Accumulations of ce11 debris were
coagulation of ce11 cytoplasm were present,
present in the lumen of many intestinal glands
together with pyknosis and karyorrhexis. In
-. 302 -
Fig. 2. - Mucosa cheek. Intranuclear inclusion
Fig. 3. - Mucosa tongue. Intracytoplasmic inclusion
bodies in epithelium (A). H. & E. (X 800).
body (A) and vacuolated epithelium. H. & E. (X 500).
Fig. 2. - Muqueuse buccale. Inclusions intra-
Fig. 3. - Muqueuse linguale. Inclusions intracyto-
nucléaires dans l’épithélium. H. & E. (X 800).
plasmiques (A) et épithélium vacuolé. H. & E.
(X 500).
Fig. 4. - Ileum. Destruction of viili and accumu-
Fig. 4. - Tleon. Destruction des villosités et accumu-
lation of debris in lumen of glands. H. & E. (X 125).
lation des débris dans la lumière de la glande. H. & E.
(X 125).
- 303 -
Fig. 5. - Ileum. Intranuclear (A) and intracyto-
Fig. 5. - lleon. Inclusions intranucléaires (A) et
plasmic (B) inclusion bodies in epithelial cells.
intracytoplasmiques (B) dans les cellules épithéliales.
H. & E. (x 1250).
H. & E. (x 1250).
affected areas, the epithelial lining consisted
and intracytoplasmic inclusion bodies were
of irregular cellular masses, four to five cells
occasionally present.
deep (Figs. 6 and 7). Eosinophilic intranuclear
Fig. 6. - Lung.
Bronchiolitis and pneumonia.
Fig. 6. - Poumon. Bronchite et pneumonie. Dégé-
Degeneration and proliferation of bronchiolar mucosa
nérescence et prolifération de la muqueuse branchiale
(A). Gant cells in lung parenchyma
(B). H. & E.
(A). Cellules géantes dans le parenchyme pulmonaire
(x 100).
(B). H. & E. (x 100).
- 304 -
Fig. 7. - Branchial mucosa. Intracytoplasmic inclu-
Fig. 8. - Lung. Alveolar giant cell. Intranuclear
sion bodies in epithelium (A). H. & E. (X 500).
inclusion bodies. H. & E. (X 2000).
Fig. 7. - Muqueuse bronchique. Inclusions intra-
Fig. 8. - Poumon. Cellule géante alvéolaire. Inclu-
cytoplasmiques dans l’épithélium (A). H. & E.
sions intranucléaires. H. & E. (X 2000).
(x 500).
The hmg parenchyma adjacent to affected
tion initially similar to that present in the oral
bronchioles showed cellular infiltration. There
cavity but followed by a moderately intense
was proliferation from the alveolar walls and
infiltration of the cutaneous epithelium by neu-
the presence in many alveoli of large multinu-
trophil polymorphs and lymphocytes. Again
cleate giant cells. Some of these cells were
intranuclear and intracytoplasmic inclusions
degenerate with pyknotic nuclei. In others, the
were observed of similar form to those present
cytoplasm was dense and amorphous and their
in other epithelial tissues.
nuclei round or oval in shape containing large
eosinophilic inclusion bodies (Fig. 8).
DISCUSSION
Lympho-reticular tissues
‘This comparative study reveals a close simi-
The lymphoid tissues examined showed some
larity in histopathological changes produced
loss of architecture. Follicles were indistinct
by the two diseases of P.P.R. and Kata. The
and perifollicular lymphocytes absent (Figs. 9
consistency, in terms of distribution and char-
and 10). Reticulo-endothelial cells were often
acter, of necrosis in the alimentary tract is
numerous in the sinuses and a number of the
notable as are the degenerative and prolifera-
lymph nodes examined showed a scattering of
tive changes present in the respiratory mucosa
pyknotic cells throughout the cortex with occa-
and lung substance.
sional areas of necrosis (Fig. 11).
Furthermore, the occurrence of eosinophilic
c
Muco-cutaneous junctions
intranuclear and intracytoplasmic inclusion ’
bodies in the alimentary and respiratory tract
The muco-cutaneous junctions of the lips,
epithelium proved to be a common feature of
eyelids and vulva showed a necrotising reac-
the two conditions.
- 305 -
Fig. 9. - Lymph node. Oedema of subcapsular sinus.
Fig. 9. -- Ganglion lymphatique. CJZdème des sinus
LO~S of lymphoid follicles. H. & E. (X 80).
sous-capsulaires. Disparition des follicules lympha-
tiques. H. & E. (X 80).
Fig. 10. - Lymph node cortex. Involuted lymphoid
Fig. 11. - Lymph node cortex. Necrosis of lympho-
follicle with prominent mass of reticulum cells.
cytes in the deep cortex. H. & E. (X 200).
H. & E. (x 500).
Fig. 10. - Cortex ganglionnaire. Régression des fol-
Fig. II. - Cortex ganglionnaire. Nécrose des lym-
licules lymphoïdes et prolifération de cellules réticu-
phocytes du cortex profond. H. & E. (X 200).
laires. H. & E. (X 500).
- 306 -
These findings, together with the evidence
vage et de Recherches Vétérinaires at Dakar-
of earlier studies (MORNET et al. 1956;
Hann, Sénégal for his encouragement in this
WHITNEY et al. 1967), strongly suggest a
study and for his permission to publish. We
closely similar aetiological agent. It is interest-
are indebted to Mr. R.C. JAMES of the
ing also to observe that lesions of this type
Department of Veterinary Pathology, Univer-
have been described in diseases produced by
sity of Edinburgh for the photography and to
other members of the paramyxovirus group -
Miss M. MITCHELL for her help in preparing
measles, distemper and rinderpest. The two
the manuscript.
former demonstrate a giant ce11 pneumonia
This work as supported in part by a grant
(PINKERTON, SMILEY and ANDERSON,
from the Ministry of Overseas Development,
1945) with intranuclear and intracytoplasmic
and also by the ” Fond d’aide et de Coopé-
inclusions but without necrosis of the alimen-
tary tract mucosa. Rinderpest is marked by
ration “.
alimentary tract and lymphoid tissue necrosis
(THIERY, 1956) but pneumonie lesions have
not been reported.
Department of Veterinary Pathology,
Roval (DICK) School of Veterinarv
S;ud&, Veterinary Field Station, -
Easter Bush, Roslin, Midlothian,
Scotland.
ACKNOWLEDGEMENTS
Institut d’Elevage et de Médecine
vétérinaire des Pays tropicaux.
The authors wish to thank Monsieur ORUE,
Laboratoire national de 1’Elevage et
de Recherches vétérinaires.
Directeur of the Laboratoire National de TEle-
Dakar-Hann, Sénégal.
RESUMEN
Relacih histologica entre la peste de 10s pequehos rumiantes y la « Kata »
en Africa del oeste
La histopatologia comparada de la peste de 10s pequefios rumianles y
P
de la « Kata » muestra que las lesiones son identicas particularmente con
una necrosis del epitelio del tracto digestivo, una degeneracion y una
proliferacion en el epitelio del tejido pulmonar y un empobrecimiento del
tejido linfoide.
Es constante la presencia de inclusiones intranucleares e intracito-
plasmicas en 10s tejidos epiteliales.
REFERENCES
BOURDIN (P.), LAURENT (A.). «Note sur la
,,
PINKERTON (H.), SMILEY (W. L.) and ANDER-
structure du virus de la peste des petits rumi-
SON (W. A. D.)._, « Giant ce11 oneumonia with
nants ». Rev. Eh. Méd. vét. Puvs tron..
‘, 1961. 20.
, ,
inclusions : a lesion common to Hechts disease,
3, 383-386.
distemper and measles », Amer. J. Pathol., 1945,
GARGADENNEC (L.), LALANNE (A.), «La peste
21, 1, l-24.
des petits ruminants », Bull. Serv. zoorc~h. Epiz.
ROWLAND (A. C.), SCOTT (G. R.) and HILL
A.O.F., 1942, 5, 1, 16-21.
(D. H.), « The pathology of an erosive stomatitis
LAURENT (A.), « Aspects biologiques de la multipli-
and enteritis in West African dwarf goats »,
cation du virus de la peste des petits ruminants
J. Puthol., 1969, 98, 1, 83-87.
ou P.P.R. sur les cultures cellulaires », Rev. Elev.
THIERY (G.), « Hematologie, histopathologie et
Méd. vét. Puys trop., 1968, 21, 3, 297-308.
histochimie de la peste bovine », Ru. Elev. Méd.
MORNET (P.), ORUE (J.), GILBERT (Y.), THIERY
vét. Puys trop., 19.56, 9, 117-141.
(G.) and SOW MAMADOU, « La peste des petits
WHITNEY (J. C.), SCOTT (G. R.) and HILL (D. H.),
ruminants en Afrique occidentale française. Ses
« Preliminary observations on a stomatitis and
rapports avec la peste bovine », Rev. Elev. MPd.
enteritis of goats in southern Nigeria », Bull.
vét. Pays trop., 1956, 9, 313-342.
epizoot. Dis. Afr., 1967, 15, 31-41.
- 307 -
VETERINAIRE DES PAYS TROPICAUX
REVUE D’ÉLEVAGE
ET DE
MÉDECINE VÉTÉRINAIRE
*
DES PAYS TROPICAUX
a
The histological relationship hetween
« peste des petits ruminants »
and kata in West Africa
by A. C. ROWLAND and P. BOURDIN
1
Tome XXIII (nouvelle série)
No 3 - 1970
i
VIGOT FRERES, EDITEURS
23, rue de I’Ecole-de-Médecine, Paris-VI”
Rev. Elev. Méd. vét. Pays trop., 1970, 23 (3): 301-07
The histological relationship between
« peste des petits ruminants D and kata in West Africa
by A. C. ROWLAND and P. BOURDIN
S U M M A R Y
The histopathology of « Peste des Petits Ruminants (P.P.R.) » and Kata
was compared. The lesions demonstrated a close similarity, with necrosis
of alimentary tract epithelium, degeneration and proliferation in respi-
ratory epithelium and depression of lymphoid tissues. Intranuclear and
intracytoplasmic inclusion bodies occurred constantly in epithelial tissues.
RESUME
L’histopathologie comparée de la Peste des Petits Ruminants (P.P.R.)
et de la « Kata » montre que les lésions sont identiques avec en particulier
une nécrose de l’épithélium du tractus digestif, une dégénérescence et une
prolifération dans l’épithélium du tissu pulmonaire et un appauvrissement
du tissu lymphoïde.
La présence d’inclusions intranucléaires et intracytoplasmiques est
constante dans les tissus épithéliaux.
INTRODUCTION
of lesions over the lips, severe diarrhoea and
catarrhal inflammation of the respiratory tract.
For many years, a disease of the West Afri-
At post-mortem exam’ination, erosions may be
cari dwarf goat, « Peste des Petits Ruminants »
observed in the mouth, pharynx and oesopha-
(P.P.R.), has been known in West Africa
gus. In the intestine, congestion of the ileo-
(GARGADENNEC and LALANNE, 1942;
caecal valve and longitudinal folds of the large
\\
MORNET, ORUE, GILBERT, THIERY and
bowel is a common feature and in addition to
SOW MAMADOU, 1956).
respiratory tract inflammation, the lungs may
show consolidation of individual lobules.
The causal agent of P.P.R. is a paramyxo-
virus similar to, although larger than the para-
This paper compares the histopathological
;r
myxoviruses of measles, distemper and rinder-
changes observed in these two diseases. The
pest. (BOURDIN and LAURENT, 1967;
study was carried out at the Laboratoire Natio-
LAURENT, 1968).
nal de TElevage et de Recherches Vétérinaires
,
in Dakar-Hann, Dakar, Sénégal.
A transmissible disease of the West African
dwarf goat resembling rinderpest was first
described in Nigeria in 1965 (WHTTNEY,
MATERIAL AND METHODS
SCOTT and HILL, 1967; ROWLAND,
SCOTT and HILL, 1969) and provisionally
The P.P.R. sections were provided by cour-
named Kata.
tesy of the Director, M. ORUE. The Kata
The two diseases, P.P.R. and Kata, show
sections were prepared at the University of
clinically an erosive stomatitis with extension
Ibadan, Nigeria. Both the P.P.R. and the Kata
- 301 -
material had been obtained from acute experi-
gical change. Essentially, the most prominent
mental infections.
cellular changes were degenerative and necroti-
sing, sometimes overlaid by a marked prolifer-
The tissues examined were from the alimen-
ation from the surviving epithelial ce&.
tary and respiratory systems and from the
muco-cutaneous junctions. These had been
Alimentary tract
fixed in 10 per cent formol saline or Bouin’s
fluid, embedded in paraffin wax and stained
Lesions of the Upper alimentary tract devel-
by haematoxylin and eosin.
oped within the stratum spinosum and granu-
losum. Affected cells showed changes varying
from vacuolation to coagulation with nuclear
RESULTS
pyknosis and karyorrhexis. Syncytial aggre-
gations occurred from time to time (Fig. 1).
Histologically, the two diseases, P.P.R. and
Inclusion bodies were observed, both intra-
Kata, presented a similar pattern of patholo-
nuclear and intracytoplasmic in
situation
Fig. 1. - Mucosa tongue. Early lesions showing a
Fig. 1. - Muqueuse de la langue. Lésions précoces
syncytium (A), foci of necrosis (B) and vacuolation of
montrant un syncytium (A), des foyers de nécrose
the mucosal epithelium. Haematoxylin and Eosin.
(B) et une vacuolisation de la muqueuse épithéliale.
(X 200).
Hématoxyline-Eosine (X 200).
(Figs. 2 and 3). These were usually brightly
but haemorrhage was not observed. Intracyto-
eosinophilic or occasionally slightly ampho-
plasmic and intranuclear inclusion bodies,
philic, round or oval in the nucleus and often
similar in form to those in the oral cavity,
fragmented in the cytoplasm. The degenerate
were distributed throughout the mucosal epithe-
epithelium was rapidly eroded leaving only a lium (Figs. 4 and 5) in variable numbers.
scanty debris above the surviving stratum ger-
Occasionally, they were numerous.
minativum.
Respiratory system
The stomach and intestines showed necrosis
of the epithelium, both superficially and in
The respiratory tract showed mucosal necro-
the deep glands with loss of villi in the small
sis and hyperplasia. Again vacuolation and
intestine. Accumulations of ce11 debris were
coagulation of ce11 cytoplasm were present,
present in the lumen of many intestinal glands
together with pyknosis and karyorrhexis. In
-. 302 -
Fig. 2. - Mucosa cheek. Intranuclear inclusion
Fig. 3. - Mucosa tongue. Intracytoplasmic inclusion
bodies in epithelium (A). H. & E. (X 800).
body (A) and vacuolated epithelium. H. & E. (X 500).
Fig. 2. - Muqueuse buccale. Inclusions intra-
Fig. 3. - Muqueuse linguale. Inclusions intracyto-
nucléaires dans l’épithélium. H. & E. (X 800).
plasmiques (A) et épithélium vacuolé. H. & E.
(X 500).
Fig. 4. - Ileum. Destruction of viili and accumu-
Fig. 4. - Tleon. Destruction des villosités et accumu-
lation of debris in lumen of glands. H. & E. (X 125).
lation des débris dans la lumière de la glande. H. & E.
(X 125).
- 303 -
Fig. 5. - Ileum. Intranuclear (A) and intracyto-
Fig. 5. - lleon. Inclusions intranucléaires (A) et
plasmic (B) inclusion bodies in epithelial cells.
intracytoplasmiques (B) dans les cellules épithéliales.
H. & E. (x 1250).
H. & E. (x 1250).
affected areas, the epithelial lining consisted
and intracytoplasmic inclusion bodies were
of irregular cellular masses, four to five cells
occasionally present.
deep (Figs. 6 and 7). Eosinophilic intranuclear
Fig. 6. - Lung.
Bronchiolitis and pneumonia.
Fig. 6. - Poumon. Bronchite et pneumonie. Dégé-
Degeneration and proliferation of bronchiolar mucosa
nérescence et prolifération de la muqueuse branchiale
(A). Gant cells in lung parenchyma
(B). H. & E.
(A). Cellules géantes dans le parenchyme pulmonaire
(x 100).
(B). H. & E. (x 100).
- 304 -
Fig. 7. - Branchial mucosa. Intracytoplasmic inclu-
Fig. 8. - Lung. Alveolar giant cell. Intranuclear
sion bodies in epithelium (A). H. & E. (X 500).
inclusion bodies. H. & E. (X 2000).
Fig. 7. - Muqueuse bronchique. Inclusions intra-
Fig. 8. - Poumon. Cellule géante alvéolaire. Inclu-
cytoplasmiques dans l’épithélium (A). H. & E.
sions intranucléaires. H. & E. (X 2000).
(x 500).
The hmg parenchyma adjacent to affected
tion initially similar to that present in the oral
bronchioles showed cellular infiltration. There
cavity but followed by a moderately intense
was proliferation from the alveolar walls and
infiltration of the cutaneous epithelium by neu-
the presence in many alveoli of large multinu-
trophil polymorphs and lymphocytes. Again
cleate giant cells. Some of these cells were
intranuclear and intracytoplasmic inclusions
degenerate with pyknotic nuclei. In others, the
were observed of similar form to those present
cytoplasm was dense and amorphous and their
in other epithelial tissues.
nuclei round or oval in shape containing large
eosinophilic inclusion bodies (Fig. 8).
DISCUSSION
Lympho-reticular tissues
‘This comparative study reveals a close simi-
The lymphoid tissues examined showed some
larity in histopathological changes produced
loss of architecture. Follicles were indistinct
by the two diseases of P.P.R. and Kata. The
and perifollicular lymphocytes absent (Figs. 9
consistency, in terms of distribution and char-
and 10). Reticulo-endothelial cells were often
acter, of necrosis in the alimentary tract is
numerous in the sinuses and a number of the
notable as are the degenerative and prolifera-
lymph nodes examined showed a scattering of
tive changes present in the respiratory mucosa
pyknotic cells throughout the cortex with occa-
and lung substance.
sional areas of necrosis (Fig. 11).
Furthermore, the occurrence of eosinophilic
c
Muco-cutaneous junctions
intranuclear and intracytoplasmic inclusion ’
bodies in the alimentary and respiratory tract
The muco-cutaneous junctions of the lips,
epithelium proved to be a common feature of
eyelids and vulva showed a necrotising reac-
the two conditions.
- 305 -
Fig. 9. - Lymph node. Oedema of subcapsular sinus.
Fig. 9. -- Ganglion lymphatique. CJZdème des sinus
LO~S of lymphoid follicles. H. & E. (X 80).
sous-capsulaires. Disparition des follicules lympha-
tiques. H. & E. (X 80).
Fig. 10. - Lymph node cortex. Involuted lymphoid
Fig. 11. - Lymph node cortex. Necrosis of lympho-
follicle with prominent mass of reticulum cells.
cytes in the deep cortex. H. & E. (X 200).
H. & E. (x 500).
Fig. 10. - Cortex ganglionnaire. Régression des fol-
Fig. II. - Cortex ganglionnaire. Nécrose des lym-
licules lymphoïdes et prolifération de cellules réticu-
phocytes du cortex profond. H. & E. (X 200).
laires. H. & E. (X 500).
- 306 -
These findings, together with the evidence
vage et de Recherches Vétérinaires at Dakar-
of earlier studies (MORNET et al. 1956;
Hann, Sénégal for his encouragement in this
WHITNEY et al. 1967), strongly suggest a
study and for his permission to publish. We
closely similar aetiological agent. It is interest-
are indebted to Mr. R.C. JAMES of the
ing also to observe that lesions of this type
Department of Veterinary Pathology, Univer-
have been described in diseases produced by
sity of Edinburgh for the photography and to
other members of the paramyxovirus group -
Miss M. MITCHELL for her help in preparing
measles, distemper and rinderpest. The two
the manuscript.
former demonstrate a giant ce11 pneumonia
This work as supported in part by a grant
(PINKERTON, SMILEY and ANDERSON,
from the Ministry of Overseas Development,
1945) with intranuclear and intracytoplasmic
and also by the ” Fond d’aide et de Coopé-
inclusions but without necrosis of the alimen-
tary tract mucosa. Rinderpest is marked by
ration “.
alimentary tract and lymphoid tissue necrosis
(THIERY, 1956) but pneumonie lesions have
not been reported.
Department of Veterinary Pathology,
Roval (DICK) School of Veterinarv
S;ud&, Veterinary Field Station, -
Easter Bush, Roslin, Midlothian,
Scotland.
ACKNOWLEDGEMENTS
Institut d’Elevage et de Médecine
vétérinaire des Pays tropicaux.
The authors wish to thank Monsieur ORUE,
Laboratoire national de 1’Elevage et
de Recherches vétérinaires.
Directeur of the Laboratoire National de TEle-
Dakar-Hann, Sénégal.
RESUMEN
Relacih histologica entre la peste de 10s pequehos rumiantes y la « Kata »
en Africa del oeste
La histopatologia comparada de la peste de 10s pequefios rumianles y
P
de la « Kata » muestra que las lesiones son identicas particularmente con
una necrosis del epitelio del tracto digestivo, una degeneracion y una
proliferacion en el epitelio del tejido pulmonar y un empobrecimiento del
tejido linfoide.
Es constante la presencia de inclusiones intranucleares e intracito-
plasmicas en 10s tejidos epiteliales.
REFERENCES
BOURDIN (P.), LAURENT (A.). «Note sur la
,,
PINKERTON (H.), SMILEY (W. L.) and ANDER-
structure du virus de la peste des petits rumi-
SON (W. A. D.)._, « Giant ce11 oneumonia with
nants ». Rev. Eh. Méd. vét. Puvs tron..
‘, 1961. 20.
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